Family with sequence similarity 133 member B (FAM133B)

Family with sequence similarity 133 member B (FAM133B) is a protein-encoding human gene characterized by RNA binding activity[3][1]. Emerging research implicates FAM133B in oncogenic processes, specifically via gene fusions with CDK6 that may contribute to abnormal cell cycle regulation and tumorigenesis in T-cell acute lymphoblastic leukemia, as well as in the modulation of radio-resistance mechanisms in nasopharyngeal carcinoma through the lncRNA FAM133B-2, which acts as a competitive endogenous RNA for miR-34a-5p and affects CDK6 signaling[1][2]. The involvement of FAM133B in cancer processes and its potential as a biomarker suggest therapeutic relevance, though its protein family is not currently described as a typical receptor, enzyme, or other mainstream target class. There are no currently known interacting drugs, mechanisms of action beyond experimental lncRNA/miRNA/kinase pathways, or documented safety concerns for direct targeting.

Other names

FAM133BProtein FAM133BMGC40405F133B_HUMAN

Not established for clinical drugs; in studies, FAM133B-2 (a related lncRNA) acts as a competitive endogenous RNA for miR-34a-5p, influencing CDK6 levels. Drugs that affect CDK6 or modulate miR-34a-5p could indirectly impact FAM133B-2 mediated pathways.