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Target intelligence / Profile preview
Family with sequence similarity 135 member A (FAM135A)
- Target
- FAM135A
- Molecular classification
- Other (Unclassified protein)
01
Overview
Family with sequence similarity 135 member A (FAM135A) is a human protein-coding gene located on chromosome 6, with orthologs in various model organisms. Its aliases include KIAA1411 and FLJ20176. FAM135A is predicted to have functions related to hydrolase activity and acyltransferase activity, and is implicated in lipid metabolism in model organisms. In disease contexts, mutations in FAM135A have been found in some neuroendocrine tumor cell lines, while gene expression modulation has been observed in host responses to viral infection, and the gene is nominally associated with disorders such as retinitis pigmentosa and multiple myeloma. However, its role as a canonical molecular target is not established, and its functions are still being explored. No drugs currently interact with FAM135A, and it is not used as a biomarker or considered a therapeutic safety concern.
- Other names
- FAM135AKIAA1411FLJ20176protein FAM135AFamily with sequence similarity 135 member A
02
Mechanism of action
Not applicable, as there are no drugs targeting this molecule.
03
Biological functions
Transcriptional regulationCellular differentiationLipid metabolic processHydrolase activity, acting on ester bondsO-acyltransferase activityOther (Exact cellular role remains to be clarified)
04
Disease associations
Neuroendocrine tumor biologyRetinitis pigmentosaMultiple myelomaPotential role in viral infection responsesOther (low expression found relevant in ethanol-related anxiety behaviors in mice; not clinically established)
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