Family with sequence similarity 138 member F (FAM138F)

Family with sequence similarity 138 member F (FAM138F, also called F379 or F379 retina-specific protein) encodes a putative 85-amino acid peptide predominantly transcribed in the human retina[2][4][8]. The gene has no significant homology to known protein sequences outside of embedded repetitive elements, and its biological function is currently unknown[2][4]. FAM138F is associated with subtelomeric regions that are duplicated in a polymorphic manner across several chromosomes, and it is transcribed from multiple genomic locations[2]. There are currently no known enzymatic, transporter, receptor, or therapeutic target functions attributed to this gene, no established disease associations, no drugs targeting this molecule, and no known clinical biomarkers or safety concerns. FAM138F belongs to a gene family that includes similar retina-expressed proteins such as FAM138D[4]. F379 (FAM138F) is characterized by an unusual sequence composition, with embedded Alu and MIR repetitive elements, and lacks similarity to established motor, signaling, or metabolic protein domains[2][4]. No established molecular or clinical function in humans or animal models has been described for the FAM138F protein to date[2][7][8]. This target is not considered a canonical therapeutic target and the entry is potentially problematic because there is no evidence this gene/protein serves as a therapeutic target or has a well-characterized function. It lacks established molecular classification in major therapeutic target families[2][4][7][8].

Other names

F379F379 retina-specific protein