Family with sequence similarity 151 member A (FAM151A)

FAM151A is a protein-coding gene encoding a transmembrane protein mainly expressed in kidney tubules in humans. It shares homology with menorin, a nematode protein essential for dendrite branching and neuronal development. The mammalian ortholog likely contributes to neuronal connectivity, although knockout models in mice show no overt phenotype for FAM151A itself (distinct from its paralog FAM151B, which is essential for retinal function in mice). The protein contains DUF2181 domains, with partial predicted phosphodiesterase activity, but its substrates and precise function remain undefined. Variation in FAM151A (notably SNP rs11206394) has been linked to reduced risk of colorectal cancer, suggesting a role as a genetic biomarker rather than a therapeutic target. FAM151A is found in extracellular exosomes and is associated with several molecular functions through genetic, transcript, and proteomic analyses, but its direct functional roles and druggability remain uncharacterized.

Other names

FAM151AC1orf179Family with sequence similarity 151 member AMGC27169UNQ3034/PRO9836

Not applicable. No drugs are known to act on FAM151A.