Family with sequence similarity 156 member A (FAM156A)

Family with sequence similarity 156 member A (FAM156A), also known as Transmembrane protein 29 (TMEM29), is a predicted nuclear envelope-localized protein believed to enable methylated histone binding activity, though precise molecular function remains incompletely characterized[2][1]. FAM156A is expressed in various tissues, with prominent expression in testes, brain, and kidney in mouse models, and displays several splice variants including both coding and non-coding transcripts[1]. Experimental evidence suggests FAM156A responds to cellular stress (e.g., oxygen-glucose deprivation) and is associated with apoptosis, particularly in neuronal cells, potentially linking it to adaptive stress response and cell death pathways[1]. While not currently considered a therapeutic target, it is investigated as a candidate gene in neurodevelopmental disorders, such as X-linked mental retardation, and as a possible prognostic biomarker in lung adenocarcinoma patients[2]. There is currently no known drug targeting FAM156A, nor established mechanisms of action or specific safety concerns related to the modulation of this molecule[2][1].

Other names

TMEM29PRO0659Transmembrane protein 29PP12994