Family with sequence similarity 156 member B (FAM156B)

Family with sequence similarity 156 member B (FAM156B), also known as transmembrane protein 29 (TMEM29) and by several other aliases, is a protein-coding gene conserved across multiple species including humans and rodents[1]. The FAM156B gene encodes a protein that is constitutively expressed in various tissues and cell lines, with nuclear localization due to a defined nuclear localization signal (NLS) domain. While its precise function is not yet fully elucidated, experimental models suggest it is involved in cellular responses to metabolic stress and hypoxic-ischemic insult. Downregulation of FAM156B (TMEM29) expression occurs following oxygen and glucose deprivation in neural cells, coinciding with activation of cell death pathways, particularly apoptosis via caspase-3 activation. FAM156B may play a role in sustaining cell viability under stress and could become relevant for studies of brain injury and cell death, but its exact molecular and disease mechanisms in humans remain to be determined. There is currently no evidence that FAM156B is a well-established therapeutic target, nor are there known drugs that act on it or validated biomarker/safety data for clinical use[1][2].

Other names

FAM156ATMEM29TMEM29BPP12994PRO0659Transmembrane protein 29Transmembrane protein 29Bprotein FAM156Aprotein FAM156A/FAM156Bchromosome X open reading frame 44-like (CXorf44-like)