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Target intelligence / Profile preview
Family with sequence similarity 161 member B (FAM161B)
- Target
- FAM161B
- Molecular classification
- Other (centrosomal/centriolar-associated protein), Cytoskeletal-associated protein family
01
Overview
FAM161B is a member of the FAM161 protein family, which includes centrosomal and centriolar components highly conserved in vertebrates. FAM161B is homologous to FAM161A, a well-studied protein implicated in the structural integrity and scaffolding of centrioles and transition zones in ciliated cells. While FAM161B's specific function is not delineated in humans, by analogy to FAM161A, it likely participates in the organization and stability of the microtubule-based structures within the centriole or centrosome. No disease associations, interacting drugs, or use as a classic therapeutic target are currently reported for FAM161B. Its best-characterized role—by homology and classification—is as a cytoskeletal-associated centrosomal protein.
- Other names
- FAM161 centrosomal protein BCentrosomal protein FAM161BC14orf44FLJ31697c14_5547
02
Biological functions
Possible structural component of centrioles and/or centrosomesMay be involved in microtubule organization (by homology to FAM161A)Other (precise function in humans unknown)
03
Disease associations
Other (no direct roles in human disease established; for comparison, FAM161A mutations cause retinitis pigmentosa, but roles for FAM161B are not described)
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