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Family with sequence similarity 162 member B (FAM162B)
- Target
- FAM162B
- Molecular classification
- Other (protein-coding gene, not classified as a receptor, enzyme, transporter, etc.)[3][1]
01
Overview
Family with sequence similarity 162 member B (FAM162B) is a protein-coding gene that is predicted to be a membrane-associated protein, found in the plasma membrane[3][1]. It is an understudied protein with functions that are not yet fully characterized, though implicated in both developmental anomalies (such as neural crest cell regulation and Hirschsprung disease) and in cancer (with roles as a tumor suppressor candidate in lung and possible prognostic marker in prostate and oral squamous cell carcinomas). FAM162B has been highlighted in several genetic and prognostic studies but is not established as a canonical receptor, enzyme, or classical drug target[1][3]. The protein's mechanisms, interacting partners, and direct functional roles remain subjects for further research.
- Other names
- FAM162BC6orf189BA86F4.2bA86F4.2protein FAM162B
02
Biological functions
Predicted to be membrane-associated[3][1]possible roles in neural crest cell dynamics[1]involvement in regulation of developmental processes and oncogenesis (context-dependent)[1]
03
Disease associations
Hirschsprung disease[1][3]Waardenburg syndrome[3]cancer (prognostic marker/tumor microenvironment)[1]developmental anomalies[1]
04
Biomarkers
Prognostic marker in prostate adenocarcinoma (higher expression linked to favorable prognosis)[1]biomarker in oral squamous cell carcinoma immune score-based signatures[1]
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