Family with sequence similarity 163 member B (FAM163B)

FAM163B encodes a single-pass transmembrane protein predominantly expressed in neurons in the central nervous system. Its expression is highest in brain tissue, with very low or absent expression elsewhere. FAM163B is localized to the neuronal cell membrane and is implicated in neuroregulatory processes, though its precise function remains incompletely understood. Overexpression or knockdown experiments in neuronal cells show that FAM163B negatively regulates the membrane-associated synaptic scaffolding protein SAP97 and interacts with the vesicle-associated membrane protein VAPA, suggesting a role in neuronal membrane dynamics and possibly synaptic function. There is no evidence that FAM163B is currently a direct therapeutic target, nor are there known drugs acting on it. Its gene (HGNC:33277, NCBI Gene:642968) has been linked to autosomal dominant deafness, but broader disease implications remain unclear.

Other names

C9orf166Protein FAM163BCebelin-like

Not applicable (no known drugs)