Family with sequence similarity 167 member B (FAM167B)

Family with sequence similarity 167 member B (**FAM167B**) is a gene encoding a protein (sometimes called *DIORA-2*) that is highly intrinsically disordered, meaning it lacks a defined tertiary structure[1][2][5]. This protein is evolutionarily conserved and shares its family with FAM167A, but does not have homologs outside FAM167A/FAM167B and is not related to any well-characterized protein domain or motif[2]. FAM167B is 163 amino acids long, with a predicted molecular weight of approximately 18.4 kDa[2][5]. Its expression and subcellular localization are not well defined, and its biological function remains largely unknown. FAM167B is not currently recognized as a therapeutic target, biomarker, or disease gene, although its related protein FAM167A has been studied for associations with autoimmune disease risk. The gene is annotated under several previous names, most notably **C1orf90**, and "Disordered autoimmunity 2" refers to its structural property. Research on FAM167B is ongoing, with large gaps in knowledge about its cellular roles and disease relevance[1][2][5].

Other names

C1orf90MGC10820DIORA-2Disordered autoimmunity 2Protein FAM167B