Family with sequence similarity 170 member A (FAM170A)

Family with sequence similarity 170 member A (FAM170A) is a zinc finger domain-containing protein that functions as a nuclear transcription factor. It is characterized by a C2H2 zinc finger motif, allowing it to bind DNA and regulate transcription[1][2][4][7]. It is highly conserved, testis-specific, and plays a crucial role in the chromatin remodeling process during sperm development, particularly in the exchange of histones for protamines required for sperm nuclear condensation[4][6]. FAM170A interacts with chromatin remodeling proteins (including USP7, lamin B1, PIWIL1, HSPA2, CSNK1A1), facilitates nuclear translocation of USP7, and enhances deubiquitination activity required for normal spermiogenesis[4]. Deficiency causes impaired chromatin remodeling, resulting in abnormal sperm morphology and male infertility[4][6]. FAM170A is endogenously expressed in a subset of human tissues, with particularly high levels in testis. It is not currently an established therapeutic target nor associated with any known drug interactions.

Other names

Protein FAM170AZNFDZinc finger domain-containing proteinZinc finger protein ZNFDZnf domain containing protein

Not applicable. As there are no drugs known to target FAM170A, mechanisms of action for therapeutics are undetermined.