Family with sequence similarity 174 member A (FAM174A)

Family with sequence similarity 174 member A (FAM174A) is a poorly characterized membrane protein carrying a domain of unknown function (DUF1180). It is expressed in various tissues and has been implicated in diverse biological processes, including cholesterol and lipid metabolism, metabolic homeostasis, and developmental pigmentation in animal models. Recent studies have connected it to oncogenic roles, notably through the formation of fusion genes such as FAM174A-WWC1 in early-onset colorectal cancer, where the fusion protein disrupts cell adhesion and perturbs Hippo pathway signaling, increasing tumorigenic potential. Genome-wide analyses also suggest its involvement in metabolic syndrome and rare variants in neurodegenerative disease, but direct therapeutic targeting, established disease biomarkers, or drug interactions for FAM174A remain undocumented. Its precise mechanism(s) and molecular partners remain largely unknown and warrant further research.

Other names

Membrane protein FAM174ANS5ATP6TMEM157UNQ1912/PRO4371HCV NS5A-transactivated protein 6UNQ1912hepatitis C virus NS5A-transactivated protein 6hepatitis C virus nonstructural protein 5A trans-activated protein 6Transmembrane protein 157HGS_RE408