Family with sequence similarity 177 member A1 pseudogene 1 (FAM177A1P1)

FAM177A1P1 is a pseudogene related to the family with sequence similarity 177 member A1 (FAM177A1) gene. Pseudogenes are genomic DNA sequences similar to normal genes but are typically non-functional due to mutations, deletions, or truncations affecting their coding potential. While some pseudogenes can exert regulatory effects at the RNA level—such as producing siRNAs or acting as miRNA decoys—the specific biological or pathophysiological role of FAM177A1P1 has not been established. As a non-protein-coding pseudogene, it is not considered a therapeutic or clinical drug target[2]. FAM177A1 (not the pseudogene) encodes a Golgi-complex-localized protein involved in immune regulation and negative regulation of cell proliferation and inflammation, with some disease relevance (e.g., susceptibility to autoimmune conditions, neurodevelopmental disorders)[1][3][4]. FAM177A1P1 refers to a presumed pseudogene, which does not encode the functional FAM177A1 protein and for which drug targeting or therapeutic relevance is not established. Pseudogenes may sometimes have regulatory RNA functions, but specific evidence for FAM177A1P1 is not found in the current literature[2]. If the intended target was the functional FAM177A1 protein, not its pseudogene, the canonical target should be 'Family with sequence similarity 177 member A1 (FAM177A1)', which is a distinct entity and is sometimes considered for disease association or immune modulation[1][3][4].

Other names

FAM177A1P1