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Family with sequence similarity 178 member B (FAM178B)
- Target
- FAM178B
- Molecular classification
- Other (unclassified protein; does not fit canonical therapeutic target classes such as receptor, enzyme, transporter)
01
Overview
Family with sequence similarity 178 member B (FAM178B) is a protein-coding gene in humans, most highly expressed in skeletal muscle and various regions of the brain[1][4][5]. The protein is primarily composed of alpha-helices and may adopt a coiled-coil tertiary structure[1]. While its precise biological function remains unclear, strong expression in the central nervous system and associations with diseases like glioma and autism spectrum disorder suggest potential roles in neuronal physiology and disease susceptibility[2][3]. FAM178B has several transcript isoforms, and its high evolutionary conservation across vertebrates and invertebrates points to a functionally significant, though as yet undefined, biological role[1]. It is not catalogued as a canonical therapeutic target (receptor/enzyme/transporter), nor is it the focus of current drug development or clinical biomarker use[1][3].
- Other names
- FAM178BHSPC234LOC51252protein FAM178B
02
Biological functions
May be involved in cell adhesionPossibly functions in the central nervous system, with strong expression in skeletal muscle and various brain regions (including corpus callosum, trigeminal nerve, spinal cord, hippocampus, and olfactory regions)Related proteins play roles in DNA damage response and genomic stability, but this is inferred from a paralog, not directly demonstrated for FAM178B
03
Disease associations
Genetic association with glioma risk; increased expression in specific brain regions is linked to higher glioma susceptibilityAssociated with autism spectrum disorder (through genetic studies)Potential connection to body mass index and bipolar disease by locus association, but not demonstrated as a causative gene
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