Family with sequence similarity 181 member B (FAM181B)

FAM181B is a conserved nuclear protein encoded by the *FAM181B* gene in humans (NCBI Gene ID: 220382). It belongs to the FAM181 gene family and is thought to play diverse roles during embryonic development and in adult physiology. Its expression is cyclic in the presomitic mesoderm of murine embryos in phase with Notch-regulated targets, suggesting a role in regulating somitogenesis. FAM181B directly interacts with TEAD transcription factors via an Ω-loop and a conserved LxxLF motif, indicating a regulatory function within the Hippo pathway that may influence transcriptional programs required for tissue development, particularly in the nervous system. While it has emerged in some association studies (e.g., with growth traits in chickens), functional disruptions do not produce obvious phenotypes in mice, potentially due to redundancy with the related protein FAM181A.

Other names

FAM181BProtein FAM181BLOC220382MGC33846

Not applicable, as no drugs are known to interact with FAM181B