Family with sequence similarity 187 member A (FAM187A)

**Family with sequence similarity 187 member A (FAM187A)** is a protein-coding gene in humans, located on chromosome 17 and encoding a 413-amino-acid polypeptide that is predicted to contain an immunoglobulin-like V-type domain[1][3][5]. The protein may be associated with membranes, but there is no verified experimental evidence for a defined structure or biological role[3][9]. Computational structure modeling by AlphaFold suggests the presence of ordered domains, but the proposed structural features have not been experimentally validated[3]. Function prediction is limited to computational analysis, which implies possible involvement in protein homodimerization; no specific cellular or physiological role has been established[1]. There are no reports directly connecting FAM187A to human diseases, pathophysiological pathways, or therapeutic intervention[1][4][5]. FAM187A has one important paralog, **FAM187B**, with similarly undefined function[1][5]. No drugs, biomarkers, or safety concerns have been identified. Scientific literature currently lacks experimental evidence for clear biological activity, molecular interactions, or clinical relevance, and the protein is not considered a validated therapeutic target. Alias and database accession numbers include RGD1307851, A6NFU0 (UniProt), ENSG00000214447 (Ensembl), and HGNC:35153[1][5][6].

Other names

FAM187AIg-like V-type domain-containing protein FAM187ARGD1307851A6NFU0 (UniProt identifier)