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Family with sequence similarity 208 member A (TASOR) (TASOR)
- Target
- TASOR
- Molecular classification
- Chromatin-binding protein, Transcriptional regulator, Epigenetic silencing factor, HUSH complex component
01
Overview
TASOR (Family with sequence similarity 208 member A) is a chromatin-binding protein that operates as part of the HUSH complex to maintain gene silencing through epigenetic modification. TASOR recruits histone methyltransferase SETDB1 and MORC2, promoting deposition of repressive histone marks (H3K9me3) at specific genomic loci and silencing retrotransposons, unintegrated viral DNA, and genes within introns. It is essential for early embryonic development and plays roles in spindle apparatus organization. TASOR has been studied in relation to cancer and development, but direct therapeutic applications are currently limited.
- Other names
- Retinoblastoma-associated protein RAP140Transgene activation suppressor proteinCTCL tumor antigen Se89-1Protein FAM208AChromosome 3 open reading frame 63Retinoblastoma-associated protein 140Protein TASORTransgene activation suppressorC3orf63
02
Mechanism of action
Not applicable, as no drugs are listed; if targeted, would likely involve inhibition of epigenetic silencing or chromatin modulation.
03
Biological functions
Maintenance of transcriptional silencingChromatin bindingProtein localization to heterochromatinSilencing of transposable elementsRepression of retrotransposonsOrganization of spindle poles and assembly during embryonic zygotic division (by similarity)
04
Disease associations
Possible involvement in cancer, including cutaneous T-cell lymphoma (CTCL) and potentially anal squamous cell carcinoma (paralog TASOR2)Roles in developmental disorders (based on essential function in early embryogenesis, by similarity)Other disease associations are still being explored.
05
Safety considerations
Not specifically reported, but targeting molecules involved in chromatin regulation may disrupt normal gene expression, causing off-target effects or developmental toxicity.
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