Family with sequence similarity 210 member B (FAM210B)

Family with sequence similarity 210 member B (FAM210B) is a mitochondrial membrane protein with roles in regulating mitochondrial energy metabolism and erythroid differentiation[1]. It is expressed as an adaptor protein associated with subunits of mitochondrial ATP synthase, facilitating proper oxidative phosphorylation and ATP production in erythroid cells[1]. Loss of FAM210B alters mitochondrial metabolism by decreasing oxidative phosphorylation and increasing glycolysis, promoting changes in cellular differentiation and metabolism[1][2]. In cancer, reduced expression of FAM210B correlates with increased metastasis and poorer survival, and its depletion drives metabolic reprogramming that enhances invasive potential through multiple signaling and metabolic pathways[2]. FAM210B is predominantly localized on the mitochondrial outer membrane and is essential for normal mitochondrial function in both erythroid and cancer cells[2]. It belongs to the DUF1279 domain protein family[2].\n\nKey evidence indicates important roles in mitochondrial metabolism but does not support its classification as a pharmacological target, receptor, or enzyme, and there are no direct therapeutic drugs or known actionable safety challenges at this time[1][2].

Other names

Protein FAM210B, mitochondrialFAM210BC20orf108PSEC0265dJ1167H4.1DKFZP434A1114LOC1161515A3Transmembrane protein C20orf108