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Family with sequence similarity 215 member A (non-protein coding) (FAM215A)
- Target
- FAM215A
- Molecular classification
- Long non-coding RNA (lncRNA), Other
01
Overview
Family with sequence similarity 215 member A (non-protein coding) (FAM215A) is a human long non-coding RNA (lncRNA) gene, not a protein-coding gene. It is also known as APR-2, C17orf88, LINC00530, or apoptosis-related protein 2. FAM215A has been shown to promote malignant phenotypes in acute myeloid leukemia (AML), enhancing cell viability, relieving cell cycle arrest, and suppressing apoptosis. Knockdown of FAM215A in AML cell lines leads to cell cycle arrest and increased apoptosis, with changes in expression of apoptosis-related proteins. FAM215A expression is upregulated in AML, and it is correlated with cell proliferation and poor prognosis. It may also be associated with other malignancies, such as glioma and ovarian cancer, but currently, it is not established as a therapeutic drug target or receptor.
- Other names
- APR-2C17orf88LINC00530Long intergenic non-protein coding RNA 530Apoptosis-related protein 2
02
Biological functions
Cell proliferationModulation of cell apoptosisModulation of cell cycle and programmed cell death
03
Disease associations
Cancer (specifically acute myeloid leukemia)Glioma susceptibilityOvarian cancer
04
Biomarkers
Prognostic biomarker for acute myeloid leukemia
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