Family with sequence similarity 216 member A (FAM216A)

Family with sequence similarity 216 member A (FAM216A) is a protein encoded by the human FAM216A gene (also known as C12orf24), located at chromosome 12q24.11[1][3]. It is predicted to be an intracellular, predominantly nuclear, protein of 273 amino acids with no well-characterized domains or established molecular function[1][3]. FAM216A is mainly expressed in the testis (especially Sertoli cells) and in the brain, with lower expression in many other tissues[1][4]. No biochemical activity, signaling function, or direct disease mechanism has been established. The protein is uncharacterized, not recognized as a receptor, enzyme, transporter, or therapeutic target. Some protein-protein interactions have been computationally predicted with factors involved in cell cycle and apoptosis (e.g., MAGEA10, DKC1)[1], but these require experimental validation. Disease associations with hematologic cancers and carboxypeptidase N deficiency have been reported based on genetic studies, but the causal or mechanistic relationships remain unknown[3]. There are no drugs or known mechanisms of drug action targeting FAM216A. FAM216A is not considered a therapeutic target based on current evidence.

Other names

FAM216AC12orf24HSU79274protein FAM216Auncharacterized protein C12orf24protein predicted by clone 23733