Family with sequence similarity 217 member A (FAM217A)

Family with sequence similarity 217 member A (FAM217A) is a protein-coding gene of currently uncharacterized molecular function, belonging to the FAM217 protein family[1][5]. The major known aliases include C6orf146 and Protein FAM217A[1][5]. FAM217A is expressed in various tissues and cell lines; protein expression has been detected in several normal and cancerous tissues, but its specific physiological role is not defined[6][11]. Available data associate FAM217A with biological processes tied to meiosis—specifically, resolution of meiotic recombination intermediates, meiotic gene conversion, male meiosis chromosome segregation, and synaptonemal complex assembly—implying potential involvement in germ cell development or spermatogenesis[7]. FAM217A is not currently established as a therapeutic target, such as a receptor, enzyme, transporter, or transcription factor; there is no evidence for direct drug interactions or use as a therapeutic biomarker[5][3]. Disease associations are suggested by altered methylation patterns in acute myeloid leukemia (AML), indicating a possible but unconfirmed role in cancer biology, although its direct function in pathogenesis remains unknown[1][6]. The protein’s structural or functional classification beyond “other” is not established; there are no described ligands, enzymatic activities, or known signaling roles[5]. Further research is needed to define its molecular function and clinical significance.

Other names

C6orf146Protein FAM217AMGC43581Uncharacterized protein C6orf146