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Family with sequence similarity 220 member A (FAM220A)
- Target
- FAM220A
- Molecular classification
- Other (Not a classical receptor, enzyme, ion channel, transporter, or transcription factor; best classified currently as a STAT-interacting regulatory protein)
01
Overview
Family with sequence similarity 220 member A (FAM220A) encodes a protein that interacts with STAT3 and promotes its dephosphorylation, thereby negatively regulating STAT3 transcriptional activity. FAM220A is expressed intracellularly, predominantly within the nucleus and acrosomal vesicle. Despite its widely conserved sequence and multiple aliases, its precise physiological functions and disease associations are still largely uncharacterized; current evidence points mainly to its role as a modulator of STAT signaling through protein-protein interaction and regulation of phosphatase activity. There is no established therapeutic targeting, associated drugs, or biomarker utility for FAM220A at present.
- Other names
- C7orf70SIPAR (STAT3-interacting protein as a repressor)ACPIN1Acrosomal protein 1MGC12966SMIM10L3SAGSIN1
02
Biological functions
Negative regulation of STAT3 activity through promoting its dephosphorylationIntracellular signal transductionNegative regulation of transcription by RNA polymerase II (by modulating STAT3)
03
Disease associations
Other (No clear or direct association with specific diseases; indirect relevance possible via STAT3 signaling pathway dysregulation, which is implicated in inflammation and cancer)
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