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Family with sequence similarity 225 member A (non-protein coding) (FAM225A)
- Target
- FAM225A
- Molecular classification
- Long noncoding RNA (lncRNA), Non-protein coding RNA, Other
01
Overview
Family with sequence similarity 225 member A (FAM225A) is a cytoplasm-localized long noncoding RNA (lncRNA) that acts as a competitive endogenous RNA (ceRNA), particularly by sponging microRNA-326 and thus modulating the expression of PADI2, an oncogene implicated in gastric cancer. Elevated FAM225A expression is associated with increased proliferation, invasion, and metastasis in gastric cancer cells, higher tumor stage, and poor patient prognosis. While FAM225A is functionally important in tumor biology, it is not a receptor, enzyme, or classical drug target, and no drugs are known to interact with it. Its overexpression might serve as a biomarker for aggressive tumor behavior in gastric cancer[1][2].
- Other names
- DKFZp686A0127C9orf109LINC00256ANCRNA00256ALong intergenic non-protein coding RNA 256ANon-protein coding RNA 256AFAM225A
02
Mechanism of action
Not applicable; does not have known drug-targeting mechanisms
03
Biological functions
Regulation of cell proliferationRegulation of cell migrationRegulation of cell invasionCompetitive endogenous RNA (ceRNA) acting as a molecular sponge for microRNAsModulation of gene expression at the post-transcriptional level[1]
04
Disease associations
Cancer (notably gastric cancer)[1]Possible involvement in glioma susceptibility and retinitis pigmentosa (genetic association only)[2]Other
05
Safety considerations
None known; not a therapeutic target
06
Interacting drugs
None known
07
Biomarkers
FAM225A expression (prognostic biomarker for gastric cancer outcomes and tumor characteristics)[1]
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