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Family with sequence similarity 227 member A (FAM227A)
- Target
- FAM227A
- Molecular classification
- Other (uncharacterized protein; no known receptor, enzyme, channel, transporter, or canonical domain/family assigned)
01
Overview
Family with sequence similarity 227 member A is a protein-coding gene mapped to chromosome 22q13.1, predicted to be predominantly nuclear with highest expression in the fallopian tube, testis, and pituitary gland[2][3][11][12]. The protein has several isoforms and predicted nuclear localization sequences, phosphorylation sites, and sequence motifs, but its biological role remains uncharacterized. Deletions in the genomic region may be linked to cancers and developmental disorders, but no drugs or targeting agents exist for this molecule, and it is not a recognized therapeutic target at present[3]. Human and rat orthologs exist, but only in rat have some contaminant/drug interactions been noted, and their relevance to human biology is unclear[9].
- Other names
- FAM227Aprotein FAM227Afamily with sequence similarity 227 member A
02
Mechanism of action
no drugs or targeted therapies described; mechanism unknown
03
Biological functions
Other (function currently unknown; putative nuclear protein; motifs and post-translational modifications described, but no characterized biological role)
04
Disease associations
Cancer (gene deletion in region 22q13 linked to breast, colorectal, and prostate cancers)Developmental disorders (gene deletion associated with lung abnormality, atrial septum defect, small size for gestational age, sensorineural hearing loss)Diamond-Blackfan Anemia 4Branchiootorenal Syndrome 1
05
Safety considerations
no direct safety or therapeutic challenges characterized because it is not an established clinical target
06
Interacting drugs
None confirmed for human FAM227A. In rat ortholog, interacts with 2,3,7,8-tetrachlorodibenzodioxine, 6-propyl-2-thiouracil, and alpha-estradiol, but relevance to human target is unestablished
07
Biomarkers
not described as a biomarker for patient selection or monitoring
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