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Family with sequence similarity 227 member B (FAM227B)
- Target
- FAM227B
- Molecular classification
- Other (protein of unknown function; not classified as receptor, enzyme, transporter, etc.), Nuclear protein
01
Overview
Family with sequence similarity 227 member B (FAM227B) is a nuclear protein whose gene is located at chromosome 15q21.2. The protein is highly expressed in the testis, kidney, adrenal, and thyroid, with lower expression in many other tissues. It contains domains of unknown function and is predicted to be localized to the nucleus, possessing multiple nuclear localization signals and a vacuolar targeting motif. While its precise biological role is not yet characterized, evidence links FAM227B to differential methylation in fertility, cancer risk loci for oral, breast, and lung cancers, and differential expression in cardiovascular disease. The gene participates in fusion events (e.g., SUGP2-FAM227B) associated with pan-cancer fusion gene contexts. There are currently no drugs or direct mechanisms modulating FAM227B, making it primarily an investigational protein with clinical correlations but not a recognized therapeutic target.
- Other names
- FAM227BC15orf33FLJ32800MGC57432family with sequence similarity 227 member B
02
Biological functions
UnknownPredicted nuclear localizationLikely involved in processes related to chromatin or nuclear activity, given localization and gene associations
03
Disease associations
Cancer (related genetic risk variant/locus in oral cancer, breast cancer, lung cancer)Cardiovascular disease (differential expression noted)Possible role in fertility (differential methylation in spermatozoa)Other (disease association by location and gene regulation, but not yet mechanistically described)
04
Biomarkers
Differential methylation status of FAM227B (in spermatozoa fertility studies)Differential gene expression in cancer (oral, breast, lung)
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