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Family with sequence similarity 228 member B (FAM228B)
- Target
- FAM228B
- Molecular classification
- Other (no evidence for common functional families like receptor, enzyme, transporter, or transcription factor)
01
Overview
Family with sequence similarity 228 member B (FAM228B) encodes a protein of unknown function. The gene is ubiquitously expressed in human tissues, including the brain, and may play a general but not currently characterized cellular role[2][3]. No molecular family features typical of receptor, enzyme, or transporter classes have been established, and it is not considered a canonical therapeutic target. Recent studies demonstrate that FAM228B RNA expression is altered in the brains and blood of individuals with major depressive disorder, especially in those treated with antidepressants, and may correlate with treatment response, suggesting its utility as a peripheral biomarker for psychiatric treatment efficacy. However, no direct functional mechanism, drug interaction, or disease involvement has been defined[2][3].
- Other names
- Protein FAM228BUPF0638 protein BFAM228B
02
Mechanism of action
None known (no drugs act directly on this protein)
03
Biological functions
Unknown (no confirmed function, but possibly involved in general cellular processes due to ubiquitous expression)
04
Disease associations
Other (potential biomarker for antidepressant response in major depressive disorder; no direct disease mechanism known)
05
Safety considerations
None reported (no data on therapeutic targeting or known adverse effects)
06
Interacting drugs
None known (no direct interaction with drugs reported)
07
Biomarkers
Potential marker for antidepressant response (escitalopram, others), as altered RNA expression of FAM228B was associated with treatment response in MDD cohorts
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