Family with sequence similarity 230 member B (non-protein coding) (FAM230B)

Family with sequence similarity 230 member B (FAM230B) is a long non-coding RNA (lncRNA) gene, not encoding a protein, localized to both the nucleus and cytoplasm[1][3][4]. FAM230B has been reported as highly upregulated in certain cancers, including colorectal, gastric, and papillary thyroid cancer[1][3]. In colorectal cancer, FAM230B participates in tumor cell proliferation by suppressing the maturation of the tumor-suppressive microRNA miR-1182, thereby promoting tumor growth and viability[1]. In other cancers, FAM230B acts by sponging specific microRNAs (e.g., miR-378a-3p in papillary thyroid cancer and miR-27a-5p in gastric cancer), leading to upregulation of oncogenic target genes and enhanced tumor progression[1]. There is currently no evidence that FAM230B functions as a typical drug target (e.g., receptor, enzyme, transporter), nor are there drugs known to specifically target this lncRNA[3]. Its biological and pathological relevance is still being actively studied, and it may serve as a potential biomarker or therapeutic target once more is known about its mechanism and regulation[1][3]. Notes: - FAM230B is not a receptor, protein, or a member of classic pharmacological target classes; it is a long non-coding RNA (lncRNA)[1][2][3][4]. - There are no approved drugs acting directly on FAM230B, and it is not established as a direct therapeutic target in drug development databases[3][4]. - Its main implication, based on current literature, is in oncogenic processes via regulation of microRNA maturation and cellular proliferation, not via direct ligand or drug interaction[1].

Other names

FLJ46366FAM230Bfamily with sequence similarity 230 member B (non-protein coding)