Family with sequence similarity 230 member J (FAM230J)

Family with sequence similarity 230 member J (FAM230J), also known as LINC01660 or long intergenic non-protein coding RNA 1660, is a long non-coding RNA (lncRNA) gene located on chromosome 22 (chr22:18361820-18391105, human genome assembly hg38)[1][3]. As with most annotated lncRNAs, FAM230J does not encode a protein but is thought to function indirectly, potentially via regulation of gene expression, chromatin structure, or RNA–protein interactions, in ways analogous to other characterized lncRNAs[2][4][6]. The biological function, disease association, and actionable drug interactions of FAM230J are not established in the current literature, and it is not generally considered a therapeutic target[1][3]. Key details: - **Canonical name**: "Family with sequence similarity 230 member J" is the formally accepted gene symbol in the Human Gene Nomenclature Committee and major databases[1][3]. - **Abbreviation**: FAM230J is the primary abbreviation[1][3]. - **Aliases**: LINC01660, long intergenic non-protein coding RNA 1660, LOC729461 are recorded aliases[1][3][7]. - **Molecular classification**: FAM230J belongs to the "long non-coding RNA" (lncRNA) class—these are RNA transcripts longer than 200 nucleotides that do not encode proteins[2][4]. It is sometimes annotated as a "long intergenic non-protein coding RNA"[1]. - **Function and disease roles**: No experimentally validated function, molecular pathway, or disease involvement for FAM230J has been reported. Most lncRNAs are involved in gene regulation, epigenetic modification, or RNA processing, but individual roles are largely uncharacterized unless experimentally validated[2][4][9][10]. There is no current evidence linking FAM230J with cancer, inflammation, or other diseases, unlike other lncRNAs such as LINC00460 or Cyrano[8][10]. - **Therapeutic targeting**: FAM230J is not considered a drug target, receptor, enzyme, transporter, or related actionable molecule. No known drugs interact with it, and there is no described mechanism of action, biomarker use, or established clinical safety concern[1][3]. - **Informatics**: Though included in gene and tissue databases, all public records indicate that annotation for FAM230J is limited to identification and basic genomic features, with no known function or clinical relevance[1][3][7]. In summary, FAM230J is a human long non-coding RNA gene with no validated molecular function, disease association, or therapeutic targeting as of now. Its main importance is as a genomic locus; further research would be required to clarify any biological or clinical role.

Other names

LINC01660long intergenic non-protein coding RNA 1660FAM230JLOC729461