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Target intelligence / Profile preview
Family with sequence similarity 234 member B (FAM234B)
- Target
- FAM234B
- Molecular classification
- Membrane-associated protein, Protein-coding gene, Beta-propeller domain-containing, Other (not classified as receptor, enzyme, transporter, etc.)
01
Overview
Family with sequence similarity 234 member B (FAM234B) encodes a predicted single-pass membrane protein, predominantly expressed in brain and several other tissues, including cytoplasm, Golgi apparatus, and microtubule organizing centers[1][6][7][8]. In cancer, especially luminal subtype breast tumors, FAM234B is upregulated and correlates with clinical features such as hormone receptor positivity, lymph node metastasis, and tumor stage[2][4]. Gene set enrichment analyses show FAM234B is implicated in membrane transport and cytoskeletal dynamics, and inversely correlated with immune response activity[2]. No approved drugs currently target FAM234B, but its role as a prognostic marker and candidate therapeutic target is under investigation in oncology[2][4]. It is also linked to rare developmental syndromes according to OMIM[7].
- Other names
- FAM234BKIAA1467protein FAM234B8430419L09RikmKIAA1467RGD1306151
02
Mechanism of action
None described in current literature; mechanism not established for drug targeting
03
Biological functions
Membrane transportCytoskeleton organizationVesicle-mediated transportNegative association with immune response functionsMicrotubule-based movement
04
Disease associations
Cancer (prognostic marker in luminal breast cancer, potentially a therapeutic target)Intellectual developmental disorders, Temtamy syndrome (from OMIM)
05
Safety considerations
None reported; therapeutic targeting is still hypothetical and not associated with known adverse effects
06
Biomarkers
Overexpression in luminal breast cancer is associated with poor prognosis
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