Family with sequence similarity 237 member B (FAM237B)

Family with sequence similarity 237 member B (FAM237B) is a protein-coding gene originally misannotated as non-coding, now recognized as encoding a conserved secreted microprotein found across species including humans, mice, and chickens. FAM237B is expressed in the arcuate nucleus of the hypothalamus and is implicated in appetite regulation; in mice, knockout or central administration studies demonstrated an orexigenic effect (increased feeding), consistent with findings in chickens. Molecularly, it may activate the GPR83 receptor via GNAQ signaling. Disease associations are minimal but include possible involvement in Stickler syndrome at the gene level. Despite detectable extracellular protein expression, its role as a human drug target is unestablished, and no drugs, biomarkers, or safety profiles are known.

Other names

FAM237Bfamily with sequence similarity 237 member Bprotein FAM237Bneurosecretory protein GMNPGM

Not established for any approved drug; preclinical recombinant protein acts as an orexigenic factor via central administration in rodents, possibly activating GPR83/GNAQ signaling