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Family with sequence similarity 241 member B (FAM241B)
- Target
- FAM241B
- Molecular classification
- Other (contains a domain of unknown function, DUF4605, and is classified as a membrane-associated protein but does not belong to well-defined large families like receptor, ion channel, enzyme, transporter, or transcription factor)
01
Overview
Family with sequence similarity 241 member B (FAM241B) encodes a small protein (121 amino acids) containing a domain of unknown function (DUF4605), conserved from primitive multicellular eukaryotes to vertebrates[1]. FAM241B is predicted to localize to intracellular membranes, primarily lysosomes and the endoplasmic reticulum, and may play a role in lysosome homeostasis and protein trafficking[1][4][5][2]. While widely expressed in human and mouse tissues, experimental knockout of FAM241B in mice does not generate a visible phenotype or physiological deficit, suggesting functional redundancy or a specialized non-essential function[1]. There is currently insufficient evidence to associate FAM241B with major disease processes or to categorize it as a therapeutic target, and its precise molecular and biological functions require further study[1][3][5].
- Other names
- C10orf35protein FAM241Buncharacterized protein C10orf35
02
Biological functions
Lysosome homeostasis (predicted)Endoplasmic reticulum biology (predicted)Protein trafficking (suggested by interaction partners but not experimentally verified)
03
Disease associations
Developmental delay (rare single patient variant)Yunis-Varon syndrome (association noted but not mechanistically established)Other (no strong disease associations identified)
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