Family with sequence similarity 247 member B (FAM247B)

FAM247B refers to an evolutionarily conserved sequence, approximately 11,231 base pairs in length, repeated within human chromosome 22 through segmental duplications. This DNA region is implicated as a nucleation site for the emergence of new genes at conserved chromosomal loci, and has contributed exonic sequences to several protein-coding genes during evolution. Notably, while FAM247 elements appear in protein-coding genes as well as long non-coding RNA genes and pseudogenes, FAM247B itself is not established as a functional protein or therapeutic target[1]. Some embedded exons derived from FAM247 sequence play roles in proteins like USP18, which is involved in immune regulation, but FAM247B itself is not characterized by a defined function, interaction, or disease association. FAM247B is not a classical protein or therapeutic target; rather, it is a DNA sequence element with potential regulatory and evolutionary roles, but no direct evidence supports it as a target for drug discovery or clinical intervention[1]. If you are seeking a targetable gene or protein related to "FAM247," you may wish to instead investigate specific genes that contain FAM247-derived exonic sequences, such as USP18, which has established biological and therapeutic relevance[1].

Other names

FAM247B