Family with sequence similarity 27 member E3 (FAM27E3)

Family with sequence similarity 27 member E3 (FAM27E3) is a protein whose expression is upregulated in various cancers, including papillary thyroid carcinoma, and is associated with metastatic potential and poor prognosis[2]. It is implicated in physiological processes like embryonic development, wound healing, and tissue regeneration, but also pathological processes such as tissue fibrosis and cancer progression[1][2]. Functionally, FAM27E3 modulates the epithelial-mesenchymal transition (EMT), enhances tumor cell invasion and migration, and may promote tumor stemness and multidrug resistance through EMT[2]. Mechanistically, it appears to influence macrophage infiltration and immune microenvironment, and can regulate phosphorylation and activity of the tumor suppressor protein TP53 (p53), which may promote oncogenic phenotypes in tumors[2]. FAM27E3 is suggested as a marker for lymph node metastasis in papillary thyroid carcinoma, but there are currently no known small-molecule or antibody drugs that directly target it[2]. The detailed molecular mechanism and universality of its function in different tumors remain to be clarified.

Other names

Protein FAM27E3MGC42630FAM27A2FAM27B