Family with sequence similarity 47 member E (FAM47E)

Family with sequence similarity 47 member E (FAM47E) is a protein localized to the chromatin, cytoplasm, and nucleus, where it acts as an activator of the protein arginine methyltransferase PRMT5, promoting PRMT5-mediated histone arginine methylation and supporting chromatin-associated epigenetic gene regulation[1][3]. Overexpression of FAM47E leads to stabilization and chromatin localization of PRMT5, influencing the expression of various PRMT5 target genes and promoting cell proliferation and colony formation, suggesting an oncogenic potential through the PRMT5 axis[1]. It is not a classical therapeutic target such as a receptor, enzyme, transporter, or ion channel, but is classified under “Other” as a chromatin and transcription regulatory protein[1][3]. Currently, no drugs or targeted inhibitors of FAM47E are described in the literature, and it is not established as a clinical biomarker or safety concern.

Other names

FAM47EFLJ42946LOC100129583similar to genethonin 1FA47Eprotein FAM47E