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Family with sequence similarity 66 member C (FAM66C)
- Target
- FAM66C
- Molecular classification
- Long non-coding RNA (lncRNA), Other
01
Overview
Family with sequence similarity 66 member C (FAM66C) is a long non-coding RNA located on chromosome 12, composed of eight exons. FAM66C does not encode a protein but acts as a regulatory RNA molecule. It modulates cancer biology by functioning as a molecular sponge for oncogenic microRNAs (such as miR-574-3p in pancreatic cancer and miR-339-3p in lung adenocarcinoma), thereby affecting cell proliferation, apoptosis, and metastasis. Reduced FAM66C expression is associated with poor prognosis and advanced stages in several cancers. Evidence also implicates FAM66C in regulating hypoxia-related pathways, immune response, and the tumor microenvironment. Currently, FAM66C is primarily of interest as a biomarker and as a subject of mechanistic cancer biology research rather than as a therapeutic target[1][2][5].
- Other names
- lncRNA FAM66CFamily with sequence similarity 66 member CLINC00625
02
Biological functions
Modulation of cell proliferationRegulation of apoptosisRegulation of cancer cell migration and invasionSponging (sequestering) of microRNAs (such as miR-574-3p and miR-339-3p) to modulate gene expressionRegulation of hypoxia-related pathways and transcription factor activity
03
Disease associations
Cancer
04
Biomarkers
Low FAM66C expression as a prognostic biomarker for poor survival and aggressive disease in pancreatic cancer and lung adenocarcinoma (LUAD)Lymph node metastasis, TNM stage, and gender together with FAM66C levels have been identified as potential clinical biomarkers in LUAD
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