Family with sequence similarity 78 member B (FAM78B)

Family with sequence similarity 78 member B (FAM78B) is a protein of 254 amino acids, encoded by the FAM78B gene on chromosome 1q24.1 in humans[1]. It is predicted to have a molecular weight of 30 kDa and predominantly localizes to the nucleus, exhibiting a highly conserved C-terminal region across vertebrate species[1]. There is no confirmed molecular function or pathway involvement for FAM78B in current scientific databases or literature. It is ubiquitously expressed, with notably high expression in brain tissues[6][9]. FAM78B has one paralog, FAM78A, and both genes are highly conserved in evolution. Clinical studies have found statistical correlations between polymorphisms in FAM78B and chronic kidney disease, but there is insufficient evidence to directly implicate it in disease mechanisms or to consider it a validated therapeutic target[1][3]. The protein is classified as “other” because its molecular function, biological role, pathway membership, and clinical relevance remain largely uncharacterized[1][2][3][10]. The HGNC-approved gene symbol is FAM78B, and the canonical full name matches the query[8]. It is not listed as a receptor, enzyme, transporter, or validated drug target in human biology databases or in curated disease-gene association platforms[2][3][10]. No authoritative references describe clinical drugs, biomarker status, or any approved mechanism of action regarding FAM78B, nor are there safety or therapeutic challenges documented[2][3][10]. Expression data confirm presence in most tissues, especially brain, with no tissue exclusivity or enrichment noted[6][9]. Associations with disease are limited to statistical correlations with certain single nucleotide polymorphisms, mostly of uncertain pathogenicity[1][3]. In summary, Family with sequence similarity 78 member B (FAM78B) is a conserved, nuclear-localized human protein of unknown function, not currently considered a therapeutic target or receptor, and without known interacting drugs, biomarkers, or validated disease mechanisms[1][3][10].

Other names

FAM78BFam78bprotein FAM78Bfamily with sequence similarity 78 member B