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Family with sequence similarity 81 member B (FAM81B)
- Target
- FAM81B
- Molecular classification
- Other (protein of unknown function; not classified as receptor, enzyme, transporter, transcription factor, etc.)
01
Overview
Family with sequence similarity 81 member B (FAM81B) is a protein-coding gene localized to the cell nucleus whose precise molecular function remains uncharacterized. FAM81B is associated with differential expression in several cancer types, including breast cancer with PIK3CA mutations (where high FAM81B mRNA correlates with progression-free survival) and mesothelioma (where expression is higher in stroma-poor tumors), suggesting a role as a potential prognostic biomarker. Direct evidence for a role in pathogenesis or as a drug target is lacking. There are no known therapeutic drugs or mechanistic models targeting FAM81B, and its broad molecular classification and biological functions remain to be defined in detail[1][3][5][7].
- Other names
- FAM81BFLJ25333FA81Bprotein FAM81B
02
Biological functions
Other (function not well characterized; nuclear protein; may have a role in cancer biology based on expression studies)
03
Disease associations
Cancer (potential biomarker in breast cancer with PIK3CA mutations and mesothelioma)Other (studied in Trichohepatoenteric Syndrome and Carboxypeptidase N Deficiency, but no direct pathogenic link established)
04
Biomarkers
Prognostic biomarker in estrogen receptor–positive breast cancer with PIK3CA mutationspossible marker in mesothelioma
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