Family with sequence similarity 83 member A (FAM83A)

Family with sequence similarity 83 member A (FAM83A) is a proto-oncogene encoding a cytoplasmic protein involved in multiple cellular processes, including signal transduction, cell proliferation, and mitochondrial function[1][2][3][4]. FAM83A contains the evolutionarily conserved domain DUF1669 with a pseudophospholipase motif, allowing it to interact with casein kinase 1 (CK1) and various signaling proteins, but it lacks intrinsic catalytic activity[2][3]. It promotes cancer cell proliferation by activating key mitogenic signaling pathways, such as EGFR, PI3K/AKT, MAPK, and the Wnt/β-catenin pathway, where it stabilizes β-catenin by disrupting its destruction complex[3][4]. In adipocyte differentiation, FAM83A contributes to mitochondrial maintenance via interaction with CK1 and is required for proper lipid droplet formation and normal adipogenesis, implicating it in obesity and metabolic disease[1]. High FAM83A expression is associated with tumor progression and poor prognosis in several solid cancers, indicating its use as a biomarker and possible therapeutic target[2][4]. There are no current approved drugs directly targeting FAM83A, but peptide-mediated disruption of its protein-protein interactions has shown antitumor effects in preclinical studies[3][4].

Other names

Protein FAM83ATSGPMGC14128BJ-TSA-9Tumor antigen BJ-TSA-9Tumor-specific gene expressed in prostate proteinFAM83A

Small molecule or peptide inhibitors may suppress cancer cell proliferation by disrupting FAM83A-mediated Wnt/β-catenin or EGFR/PI3K/AKT/MAPK signaling, but no approved targeted drugs are documented[3][4].