Family with sequence similarity 83 member D (FAM83D)

Family with sequence similarity 83 member D (FAM83D) is a mitosis-associated scaffolding protein localized to the mitotic spindle, where it recruits protein kinase CK1α to ensure proper spindle positioning and normal cell division[5]. FAM83D binds kinesins, microtubules, and protein kinases, modulating key aspects of the cell cycle, particularly chromosome alignment and G1/S transition[3][5]. Overexpression is found in numerous cancers and is linked to tumorigenesis, progression, and poor prognosis, making it a candidate diagnostic/prognostic biomarker[1]. FAM83D influences mitogenic signaling pathways, including ERK1/2 and possibly MTOR, JUN, and MYC signaling through its effects on protein stability[3][5]. There are currently no drugs targeting FAM83D directly, and it is not classified as a traditional receptor, enzyme, or transporter[1][3][5].

Other names

FAM83Dfamily with sequence similarity 83, member DHBV X protein-associated protein 5

Not applicable; no drugs are known to act directly on FAM83D.