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Target intelligence / Profile preview
Family with sequence similarity 86 member B2 (FAM86B2)
- Target
- FAM86B2
- Molecular classification
- Enzyme (predicted protein-lysine N-methyltransferase), Protein-coding gene
01
Overview
Family with sequence similarity 86 member B2 (FAM86B2) is a human gene encoding a protein predicted to possess N-methyltransferase activity, possibly involved in protein lysine methylation and regulation of translation. Functional characterization is limited: evidence for direct biological function, disease association, or utility as a therapeutic target or biomarker is currently lacking. FAM86B2 is subject to post-translational modification including phosphorylation and ubiquitination. A variant at S33 (S33R) has been reported in uterine cancer samples, but its clinical significance remains unclear. Its closest annotated paralog is EEF2KMT, another methyltransferase active in translation-related protein modification[2][3][4][5].
- Other names
- FAM86B2Putative protein N-methyltransferase FAM86B2F86B2 protein (UniProt short label: hFAM86B2)
02
Biological functions
Methylation (predicted)Regulation of translation (predicted)Post-translational modification (as substrate for phosphorylation and ubiquitination)
03
Disease associations
Other (no established disease association, though a variant at S33 has been observed in uterine cancer samples)
04
Biomarkers
S33R variant observed in uterine cancer samples, but not established as a clinical biomarker
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