Family with sequence similarity 87 member B (FAM87B)

Family with sequence similarity 87 member B (FAM87B) is a protein-coding gene located on chromosome 11q13.4. It encodes the FAM87B protein, which is involved in cellular processes such as protein degradation and vesicle trafficking, partly by participating in the assembly of the endosomal sorting complex required for transport (ESCRT), facilitating transport from endosomes to lysosomes. Mutations in FAM87B have been associated with neurodegenerative diseases such as Charcot-Marie-Tooth disease type 2E, frontotemporal dementia with parkinsonism, and amyotrophic lateral sclerosis. FAM87B is also annotated as a long non-coding RNA in some sources and has been studied as a biomarker in glioma classification[1][3][4]. Notes on correctness: - FAM87B is not a classical therapeutic target (receptor, enzyme, etc.), and there is no evidence of drug interactions or mechanism-based pharmacology[1][3][4]. - In some contexts, the term "FAM87B" may refer to a long non-coding RNA, not a protein target, so care should be taken in interpreting its biological role or druggability[4]. - Data are limited; there is overlap and potential confusion due to its annotation as both a protein-coding gene and a non-coding RNA in different studies.

Other names

FLJ40008FAM87B