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Target intelligence / Profile preview
Family with sequence similarity 88 member C (FAM88C)
- Target
- FAM88C
- Molecular classification
- Long non-coding RNA (lncRNA), Other
01
Overview
Family with sequence similarity 88 member C (FAM88C), also called Lnc-PPRL or pterygium positively-related lncRNA (LOC102724238), is a cytoplasm-enriched long non-coding RNA identified as upregulated in pterygium, a proliferative and degenerative disease of the ocular surface. FAM88C/Lnc-PPRL promotes the proliferation, migration, and invasion of human pterygium epithelial cells by activating the PI3K/PDK1 and downstream Akt/mTOR signaling pathways. These findings suggest a functional role for FAM88C in the pathogenesis of pterygium and indicate its potential as a disease biomarker or future therapeutic target, though it is not presently an established therapeutic target in clinical settings[1][2].
- Other names
- Lnc-PPRLpterygium positively-related lncRNALOC102724238
02
Biological functions
Regulation of cell proliferationRegulation of cell migrationRegulation of cell invasionSignal transduction (via PI3K/PDK1 pathway)Cytoplasmic accumulation
03
Disease associations
Other (specifically, promotes pterygium development)
04
Biomarkers
Potential biomarker for pterygium (as an upregulated lncRNA in pterygium tissue)[2]
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