Target intelligence / Profile preview

Family with sequence similarity 98 member C (FAM98C)

Target
FAM98C
Molecular classification
Protein of unknown specific function; possible member of tRNA-splicing ligase complex (predicted only), "Other" (no evidence that it is a receptor, enzyme, transporter, ion channel, transcription factor, or histone modifier), Protein coding gene
01

Overview

FAM98C (Family with sequence similarity 98 member C) is a protein-coding gene with uncertain biological and molecular function. The protein is widely expressed in cytoplasm and nucleus across many human tissues. It is predicted to be part of the tRNA splicing ligase complex, but this function is not experimentally confirmed. FAM98C has been nominated as a candidate gene for certain rare genetic diseases (including ciliopathies), but is not directly implicated as a therapeutic target, receptor, or enzyme. Its molecular class falls under "protein of unknown function." There is no evidence for drug interactions, established disease roles outside rare genetic syndromes, or utility as a biomarker or drug target.

Other names
FAM98CFLJ44669Protein FAM98C
02

Biological functions

Predicted involvement in tRNA splicing ligase complexProtein binding (from Gene Ontology annotation, inferred from protein interaction data)Possible role in ciliary structure/function (candidate gene from ciliopathy genomic studies; not confirmed)
03

Disease associations

Candidate gene for ciliopathies (short-rib thoracic dysplasia, short rib-polydactyly syndrome, Verma-Naumoff type)Investigated in genetic association studies for prostate cancer risk (no strong direct link)

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