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Family with sequence similarity 99 member B (FAM99B)
- Target
- FAM99B
- Molecular classification
- Long non-coding RNA (lncRNA), Non-protein coding gene, Intronic sense ncRNA
01
Overview
Family with sequence similarity 99 member B (FAM99B) is a liver-specific long non-coding RNA (lncRNA), highly expressed in hepatic tissue and markedly downregulated in hepatocellular carcinoma (HCC)[2][3][4][7]. FAM99B acts as a tumor suppressor, influencing cell proliferation, migration, invasion, and metabolic pathways associated with cancer progression[2][3][4]. Its decreased expression correlates with increased HCC malignancy and poor prognosis, making it a promising biomarker for diagnosis and prediction of HCC outcomes[2]. FAM99B does not encode a protein and is not a pharmacological target but may provide mechanistic and diagnostic insights into liver cancer biology[1][2][7].
- Other names
- FAM99BDKFZp781M09150Family with sequence similarity 99 member B (non-protein coding)Multiple previous identifiers (e.g., GC00U921691, ENSG00000205865, NCBI Gene: 100132464)
02
Biological functions
Tumor suppression in hepatocellular carcinoma (HCC)Regulation of cell proliferation, migration, invasionPossible involvement in metabolic and blood coagulation pathwaysRegulating cell cycle, apoptosis, metastasis, extracellular matrix remodeling, and metabolic reprogramming
03
Disease associations
Cancer (especially liver cancer / HCC)
04
Biomarkers
Prognostic biomarker for HCC (low expression associated with poor prognosis, vascular invasion, metastasis, advanced grade)Diagnostic auxiliary biomarker for HCC, with reported sensitivity and specificity comparable to AFP
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