FANCD2 pseudogene 2 (FANCD2P2)

FANCD2 pseudogene 2 (FANCD2P2) is a human genomic pseudogene located approximately 1.76 Mb downstream of the functional FANCD2 gene[2]. Like other pseudogenes, FANCD2P2 shares substantial sequence similarity with certain exons of FANCD2 but contains multiple deletions, insertions, and mutations distinguishing it from the active gene[2]. These features make FANCD2P2 incapable of coding for a functional protein and, therefore, biologically inert in the context of DNA repair, disease, or therapeutic targeting[2][4][3]. The presence of FANCD2P2 and other pseudogenes flanking the FANCD2 locus can complicate genetic analysis and mutation mapping for Fanconi anemia, but they do not themselves contribute functional effects or disease roles[2][3][4]. The functional FANCD2 gene is a protein-coding gene central to DNA damage response and is clinically relevant in Fanconi anemia, cancer risk, and genome stability[5][6][3]. However, FANCD2P2 itself does not have therapeutic, functional, or biomarker significance. FANCD2 pseudogene 2 (FANCD2P2) is a non-coding pseudogene and not considered a therapeutic target; any information suggesting otherwise is incorrect or misattributed to the functional FANCD2 gene[2][4][3].

Other names

Fanconi anemia complementation group D2 pseudogene 2FANCD2P2