Fanconi anemia group C protein (FANCC)

Fanconi anemia group C protein (FANCC) is a key subunit of the FA core complex involved in DNA damage response, especially the repair of interstrand cross-links that block DNA replication. FANCC regulates the recruitment and activation of other FA proteins such as FANCD2 and is essential for the stability and function of the multisubunit repair complex. Deficiency or mutation leads to Fanconi anemia, a syndrome characterized by bone marrow failure, congenital abnormalities, and cancer predisposition. FANCC also has roles in cytokine signaling (STAT1 pathway), linking DNA repair to immune response and apoptosis suppression. FANCC interacts with other FA proteins (FANCA, FANCG) and is found in both cytoplasm and nucleus as part of the core complex. There are no approved drugs that specifically target FANCC, but its functional status may inform chemotherapy choice and patient management.

Other names

Fanconi anemia group C proteinFANCCFACFACCProtein FACCFA3LOC105376156

No drug directly targeting FANCC is clinically approved. In research, disruption of the FA core complex (e.g., small molecules interfering with protein-protein interactions) has been proposed to sensitize cancer cells to DNA cross-linking agents. Cellular response to DNA cross-linking agents relies on FANCC-dependent repair; thus, loss of FANCC function leads to increased sensitivity.