Fanconi anemia group D2 protein (FANCD2)

The Fanconi anemia group D2 protein (FANCD2) is a core component of the Fanconi anemia DNA repair pathway, which detects and repairs DNA interstrand cross-links—a particularly cytotoxic form of DNA damage. Upon DNA damage, FANCD2 forms a heterodimer with FANCI, and is subsequently monoubiquitinated by the Fanconi anemia (FA) core complex. This modification enables the complex to recruit downstream DNA repair factors to chromatin and coordinate repair, preserving genomic stability. Mutations in the FANCD2 gene cause Fanconi anemia (FA), characterized by progressive bone marrow failure and increased cancer risk. The term "opposite strand" does not refer to any recognized molecular entity and is likely an annotation artifact rather than a legitimate therapeutic target.

Other names

Fanconi anemia group D2FA-D2

For the pathway: monoubiquitination of FANCD2 (and FANCI) initiates repair of DNA interstrand cross-links