Fanconi anemia group G protein (FANCG)

Fanconi anemia group G protein (FANCG) is a core component of the Fanconi anemia (FA) repair pathway, responsible for repairing DNA interstrand cross-links (ICLs) that block DNA replication. FANCG is one of several proteins that together form the FA core complex, which facilitates the monoubiquitination of FANCD2 and FANCI, activating downstream DNA repair. FANCG is essential for maintaining genomic integrity by preventing chromosomal breakage during replication stress. Deficiency or mutation in FANCG causes Fanconi anemia complementation group G, leading to a phenotype of bone marrow failure, developmental abnormalities, and increased cancer risk, especially for acute myeloid leukemia and various solid tumors. FANCG-deficient cells are hypersensitive to DNA cross-linking agents (e.g., cisplatin, mitomycin C). There are no direct therapies targeting FANCG, but its genetic status is valuable for diagnosis, prognosis, and guiding the use of DNA-damaging chemotherapeutics.

Other names

Fanconi anemia group G proteinFANCGXRCC9Protein FACGFAGDNA repair protein XRCC9X-ray repair complementing defective repair in Chinese hamster cells 9

Not applicable, as there are no direct drugs targeting FANCG; indirect effects relate to hypersensitivity to cross-linking chemotherapies.