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Farnesyl Diphosphate Synthase (FDPS)
- Target
- FDPS
- Molecular classification
- Enzyme, Prenyltransferase
01
Overview
Farnesyl Diphosphate Synthase (FDPS) is an enzyme that catalyzes the sequential condensation of isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP) to form geranyl pyrophosphate (GPP), which then condenses with another IPP to produce farnesyl diphosphate (FPP). FPP is a key intermediate in the biosynthesis of cholesterol, sterols, sesquiterpenoids, triterpenoids, carotenoids, coenzyme Q (ubiquinone), dolichol, abscisic acid in plants, plastoquinone, and farnesylated proteins. FDPS activity is inhibited by bisphosphonates, drugs commonly used to treat osteoporosis.
- Other names
- FPPSFPS
02
Mechanism of action
Inhibition of FPP production, preventing post-translational modification of small GTPases.
03
Biological functions
Sterol biosynthesisSesquiterpenoid biosynthesisProtein prenylationIsoprenoid biosynthesis
04
Disease associations
Bone resorption diseasesPorokeratosis
05
Safety considerations
Impaired osteoclast function leading to altered bone remodeling
06
Interacting drugs
Bisphosphonates
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