Farnesyl diphosphate synthase pseudogene 5 (FDPSP5)

Farnesyl diphosphate synthase pseudogene 5 (FDPSP5) is a human pseudogene related to the enzyme farnesyl diphosphate synthase (FDPS). As a pseudogene, FDPSP5 does not encode a functional protein but represents a nonfunctional duplicate or processed gene related to FDPS, often arising due to mutations or loss of regulatory elements that disrupt coding potential. While active FDPS is a known enzyme in cholesterol and isoprenoid biosynthesis and an established therapeutic target for drugs such as bisphosphonates, pseudogenes like FDPSP5 are typically not directly targeted by pharmaceuticals. Evidence from other pseudogenes suggests some may have regulatory roles as RNA molecules—for instance, modulating parental gene expression via antisense transcripts, siRNAs, or acting as miRNA decoys[2]. However, no specific regulatory or disease function has been documented for FDPSP5. FDPSP5 is also listed under alternative symbols such as FDPSL5, FPSL5, and CHR39C and is classified as an unprocessed pseudogene with no confirmed enzymatic or direct biological activity[5]. If you require information on the functional, druggable enzyme, refer to farnesyl diphosphate synthase (FDPS), not FDPSP5[1][3].

Other names

Farnesyl diphosphate synthase pseudogene 5FDPSP5Farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) (FDPS) pseudogeneFarnesyl diphosphate synthase-like 5 pseudogeneCholesterol-repressible protein 39CFDPSL5FPSL5CHR39C[5]